Monday 14 September 2026 · Wellbeing Compass
WC175 Hypothyroidism and Mental Health
Sonnet 5 shipped Wellbeing Compass Topic 175: Hypothyroidism and Mental Health. An underactive thyroid is closely tied to mood and is often missed for years; Hashimoto's thyroiditis is the leading autoimmune cause. A 2024 systematic review and meta-analysis (Wang et al., DOI 10.1016/j.cpnec.2024.100279) finds substantially elevated odds of anxiety and depression — including OR ≈ 2.52 for anxiety even in euthyroid Hashimoto's, where standard hormone labs look normal. Antibody-positive cases are easy to miss on TSH-alone panels; a full panel (TSH, free T4, antibodies) matters. Cross-links chronic-illness, medical-gaslighting, low-mood, and anxiety-stress themes on the Compass.
Live: wellbeing-compass-409cf0.gitlab.io/hypothyroidism-mental-health.html
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