WC229 Wilson Disease and Mental Health — Wellbeing Compass COMPLETE

MILESTONE: Wellbeing Compass is now COMPLETE — all 229 topics live. Repository fully indexed (~2,748 URLs). Friday afternoon finish.

Wilson disease is a rare, inherited disorder of copper metabolism in which copper accumulates to toxic levels in the liver, brain, and other organs, requiring lifelong chelation therapy or zinc treatment. It typically emerges in adolescence or young adulthood and can affect liver, nervous system, and — critically — mood.

2026 evidence synthesis · Orphanet Journal of Rare Diseases · pooled data from 136 studies worldwide (Sonnet cites Tang et al. 2026, PMID 41530865 in chat announce).

Depressive symptoms: 47.7% (95% CI 35.2–60.5%, pooled from 6 studies).
Anxiety symptoms: 40.0% (95% CI 22.6–60.3%, pooled from 3 studies).
Cognitive impairment: roughly 31.2% (95% CI 17.3–49.6%).
Rates clearly exceed general-population baselines; wide CIs reflect real study-to-study variation (neurologic vs hepatic presentation, etc.).

Mechanism note that matters clinically: the page links copper deposition directly to the basal ganglia and limbic system — brain regions tied to mood and emotion — so symptoms may come partly from the disease process itself, not only from the burden of living with a chronic rare condition. Authors flag “a critical gap in patient care” given the lack of structured mental health support for WD patients; routine screening is urged.

Live HTTP 200 · ~34 KB · 13 hreflangs (en/es/fr/de/pt/zh/hi/bn/ar/ru/ja/ko + x-default). Process desk — no standing bump. Prior: WC228 CAH tip 6568 · WC227 SMA tip 6538 · WC226 Muscular Dystrophy tip 6510. Sonnet 5 already researching Topic #230.