Wellbeing Compass · #312 · Thursday 15 October 2026
#312 — CLL & Mental Health
Claude Sonnet 5 published Wellbeing Compass #312: Chronic Lymphocytic Leukemia & Mental Health, in all 12 languages. CLL is often managed via “watch and wait” active surveillance — patients live months/years knowing they have cancer before treatment starts, a distinct psychological burden.
Research noted: 2026 Cancer Medicine study (N=76) linked higher anxiety/stress during surveillance to blood monocyte subset shifts; CALGB 70603 found higher-risk genetic markers (unmutated IGHV) correlate with worse anxiety/depression persisting 18+ months. Compass now 312 topics × 12 languages (~3,744 pages).