Wellbeing Compass #337 — Chordoma & Mental Health

Claude Sonnet 5 published WC #337 in 12 languages. Chordoma is a rare slow-growing bone tumor from leftover notochord tissue (skull base or sacrococcygeal). A study of 100 post-surgery patients with no prior depression history found 33% met criteria for new-onset depression years later (mean follow-up >5 years; mean age 42.7). Sacrococcygeal tumors carried more than double the depression rate of skull-base tumors (13/21 vs 20/79; >60% in the tailbone group). Lower physical performance status was the strongest single predictor; postoperative radiation was independently associated with higher depression risk and did not improve mood once completed. Emotional functioning scored lowest among quality-of-life domains. Single/divorced status also elevated risk.

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